Target the gut
microbiome to optimize
patient health

Target the gut
microbiome to
optimize
patient health

Using cutting-edge technology and microbiome science, Pendulum has identified proprietary strains that strengthen gut barrier integrity and support metabolic health.

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Our proprietary strains support GLP-1 production naturally

GLP-1 Probiotic is formulated with bacterial strains that boost this process naturally.*

As you eat, metabolic processes are triggered in your body In the gut microbiome, the beneficial bacteria–such as Akkermansia and Butyricum–convert the fiber in your food into butyrate, and Akkermansia secretes a protein called p9 Butyrate and p9 stimulate GLP-1, the hormone that tells your pancreas to produce insulin, slowing down the emptying of your stomach This sends a signal to your brain that you’re full, reducing your appetite, helping to maintain a healthy weight
1
As you eat, metabolic processes are triggered in your body
2
In the gut microbiome, the beneficial bacteria–such as Akkermansia and Butyricum–convert the fiber in your food into butyrate, and Akkermansia secretes a protein called p9
3
Butyrate and p9 stimulate GLP-1, the hormone that tells your pancreas to produce insulin, slowing down the emptying of your stomach
4
This sends a signal to your brain that you’re full, reducing your appetite, helping to maintain a healthy weight

*Based on preclinical studies

Live vs pasteurized bacteria

Watch the full Q&A webinar on live vs. pasteurized with Dr. Colleen Cutcliffe, PhD
Webinar content is for educational purposes only
Live
Akkermansia
Pasteurized
Akkermansia
Breaks down
fibers in the gut
Colonizes
the gut
Produces postbiotics
in the colon
Associated with improved health in higher levels
Contains beneficial
bacterial components
Live Akkermansia: the gold standard in probiotic formulationLive Akkermansia: the gold standard in probiotic formulation

Live Akkermansia: the gold standard in probiotic formulation

Only live Akkermansia can consume mucin and
stimulate goblet cells to produce new mucin to
maintain gut barrier integrity.

Only live Akkermansia can work with consumed fiber
and polyphenols to colonize the gut.

The majority of studies that identify health-promoting benefits of Akkermansia in humans have looked at live bacteria; therefore, many of the mechanisms observed in live Akkermansia are not transferable to pasteurized bacterium.

Pasteurized/dead Akkermansia: limited, one-time benefitPasteurized/dead Akkermansia: limited, one-time benefit

Pasteurized/dead Akkermansia: limited, one-time benefit

Pasteurized Akkermansia does not enable the mucin regulation process for maintaining gut barrier integrity.

Pasteurized Akkermansia does not provide the important interactions and molecules produced through the synergy of diet and live beneficial microorganisms.

Amuc_1100, an outer-membrane protein of Akkermansia, is one of the only extracellular vesicles (EVs) mentioned in studies observing pasteurized Akkermansia; however, it retains only partial stability with pasteurization. Other heat sensitive enzymes found in live Akkermansia are not functional post pasteurization.

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CLINICAL TRIALS

We're Investing in Clinical Trials

We're Investing in Clinical Trials

A leader in microbiome research, Pendulum is discovering the important connections between our health and the microbiome.

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Stay informed on microbiome research and access resources for patients and providers

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