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Premium desiccant-lined packaging ensuring maximum viability
Two-year shelf life
Dosing options for tailored patient protocols
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Our proprietary strains support GLP-1 production naturally

GLP-1 Probiotic is formulated with bacterial strains that boost this process naturally.*

Learn more about the science

As you eat, metabolic processes are triggered in your body

In the gut microbiome, the beneficial bacteria–such as Akkermansia and Butyricum–convert the fiber in your food into butyrate, and Akkermansia secretes a protein called p9

Butyrate and p9 stimulate GLP-1, the hormone that tells your pancreas to produce insulin, slowing down the emptying of your stomach

This sends a signal to your brain that you’re full, reducing your appetite, helping to maintain a healthy weight

As you eat, metabolic processes are triggered in your body

In the gut microbiome, the beneficial bacteria–such as Akkermansia and Butyricum–convert the fiber in your food into butyrate, and Akkermansia secretes a protein called p9

Butyrate and p9 stimulate GLP-1, the hormone that tells your pancreas to produce insulin, slowing down the emptying of your stomach

This sends a signal to your brain that you’re full, reducing your appetite, helping to maintain a healthy weight

*Based on preclinical studies

Scientific understanding of the gut microbiome has grown exponentially

Technological advancements in bacterial DNA sequencing have led to a boom in microbiome research, enabling the identification of how keystone bacterial strains function in the gut to impact health throughout the body.

Pendulum Strains

Mucin fortifier
Akkermansia muciniphila

Primary fermenter
Bifidobacterium infantis

Butyrate producers
Clostridium butyricum
Clostridium beijerinckii
Anaerobutyricum hallii

Our strains deserve a spotlight

Precision matters. Meet the powerful ingredients behind Pendulum’s next-generation probiotics.

Akkermansia muciniphila

A highly targeted strain that can only be found in Pendulum products. Akkermansia is essential for gut health. It helps strengthen the gut lining, improves digestive health, and helps manage a healthy weight.

Clostridium butyricum

Naturally found in the human gastrointestinal tract, this strain is named for its ability to produce high amounts of the short-chain fatty acid butyrate. It has been associated with digestion support and immune health.

Clostridium beijerinckii

This novel strain produces the short-chain fatty acid butyrate, which helps the body process sugar and nourish the lining of the gut.

Anaerobutyricum hallii

This is another strain known to produce the short-chain fatty acid butyrate, to help the body process sugar and nourish the lining of the gut.

Bifidobacterium infantis

This strain breaks down a range of foods and produces the intermediate molecules that are used by the three butyrate-producing strains we have. It also helps maintain a healthy gastrointestinal tract and alleviates digestive issues.

State of the art delivery capsule

Our probiotics are encased in a plant-based, acid-resistant, delayed release capsule, so that the strains get through the stomach acid and to the gut microbiome where it can do its job.

Live vs pasteurized bacteria

Watch the full Q&A webinar on live vs. pasteurized with Dr. Colleen Cutcliffe, PhD
Webinar content is for educational purposes only

Breaks down
fibers in the gut

Colonizes
the gut

Produces postbiotics
in the colon

Associated with improved health in higher levels

Contains beneficial
bacterial components

Live
Akkermansia

Pasteurized
Akkermansia

Live Akkermansia: the gold standard in probiotic formulation

Only live Akkermansia can consume mucin and
stimulate goblet cells to produce new mucin to
maintain gut barrier integrity.

Only live Akkermansia can work with consumed fiber
and polyphenols to colonize the gut.

The majority of studies that identify health-promoting benefits of Akkermansia in humans have looked at live bacteria; therefore, many of the mechanisms observed in live Akkermansia are not transferable to pasteurized bacterium.

Pasteurized/dead Akkermansia: limited, one-time benefit

Pasteurized Akkermansia does not enable the mucin regulation process for maintaining gut barrier integrity.

Pasteurized Akkermansia does not provide the important interactions and molecules produced through the synergy of diet and live beneficial microorganisms.

Amuc_1100, an outer-membrane protein of Akkermansia, is one of the only extracellular vesicles (EVs) mentioned in studies observing pasteurized Akkermansia; however, it retains only partial stability with pasteurization. Other heat sensitive enzymes found in live Akkermansia are not functional post pasteurization.

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Help curb appetite and cravings

GLP-1 Probiotic

91% reported reduced overall food cravings**
Enhances natural GLP-1 production*
Helps maintain a healthy weight

Lower glucose spikes & A1C

Glucose Control

Reduces blood sugar
Clinically-proven
Highest potency formulation
0.6 A1C reduction†
32.5% reduction in postprandial glucose spikes†

Maintain keystone strain

Akkermansia 100

Lower dose for tailored protocols
Improves gut health
Strengthens gut lining
*Reduces gut permeability*

Replenish keystone strain

Akkermansia 500

Higher dose for tailored protocols
Improves gut health
Strengthens gut lining*
Reduces gut permeability*

Improve metabolism*

Metabolic Daily

Helps metabolize sugars & carbs*
Converts food into energy more efficiently*
Sustains energy levels

Boost probiotics with antioxidants

Polyphenol Booster

Helps protect cells for healthy aging*
Boosts Akkermansia levels for improved gut health*
Helps support natural GLP-1 production*

* Based on preclinical studies.
** Based on a consumer survey of 274 people
†Perraudeau et al 2020

Resources for you and your practice

Patient Handouts

Protocols

Factsheets

Publications

Hear from world-class healthcare providers and institutions

Top doctors and researchers recognize the potential of Pendulum's novel strains. Our prestigious advisors hold leadership positions at leading research institutions such as Johns Hopkins, Cornell, UCLA, Mayo Clinic, and Stanford Medicine.

Together, we're advancing the world's understanding of health and the microbiome.