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Groundbreaking Science Targets the
Microbiome to Help Manage Type 2 Diabetes

Pendulum Glucose Control, a first-of-its-kind formulation of both probiotics and a prebiotic, is changing the dietary management of type 2 diabetes. This formulation provides specific strains that have been proven to be missing or lacking functionality in people with type 2 diabetes—setting us apart from other probiotics on the market.

Groundbreaking Science Targets the
Microbiome to Help Manage Type 2 Diabetes

Pendulum Glucose Control, a first-of-its-kind formulation of both probiotics and a prebiotic, is changing the dietary management of type 2 diabetes. This formulation provides specific strains that have been proven to be missing or lacking functionality in people with type 2 diabetes—setting us apart from other probiotics on the market.

Clinical Results

Glucose Control:
A Targeted Approach To
Type 2 Diabetes Care

Research indicates that two imbalances in the gut microbiome are linked to the incidence of type 2 diabetes:

  1. Inability to produce the short-chain fatty acid butyrate, typically produced when the gut microbiome metabolizes some dietary fibers.
  2. Impaired functional ability to maintain the mucin layer of the gut lining. Thinning of the mucin layer results in intestinal permeability, commonly known as “leaky gut syndrome."

Mechanism of Action

Pendulum Glucose Control is a patented formulation of five anaerobic probiotic strains and the prebiotic inulin, which provides the initial food source for the probiotics. This unique synbiotic helps restore the body’s natural capabilities to produce butyrate, which helps meet the unique dietary needs of people with type 2 diabetes.

Butyrate is the primary energy source for colon cells. It binds to specific receptors within the gut mucosa and stimulates the release of the incretin hormone, glucagon-like peptide-1 (GLP-1). Among healthy people, GLP-1 promotes satiety and reduces appetite, enhances glucose-dependent insulin secretion in the beta cells, inhibits post-meal glucagon secretion, reduces glucose output from the liver, and helps regulate gastric emptying. GLP-1 is deficient in people with impaired glucose tolerance and type 2 diabetes, which contributes to hyperglycemia.

The two main ways PGC works is: It revives body’s ability to produce short chain fatty acids including butyrate, and restores the mucin lining of the gut.

Our Clinical
Studies

Prediabetes Observational Study

2021

Mayo Clinic Partnership Customer Registry

2021

Exploratory Customer CGM Study

2021

Safety and Metabolic Effects in T2D – Part II

2022

Metabolomics in T2D

2022

Emerging Role of the Microbiome
in Type 2 Diabetes

ADCES In Practice Journal

The Therapeutic Optimization of the Gut Microbiota in Diabetes Management

Read Article

See Our ADA TV Feature

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Akkermansia muciniphila

The gut-lining builder

Microbe involved in maintaining healthy mucin layer, which leads to increased diversity within the microbiome and blocks the entry of inflammatory substances into the bloodstream.

Clostridium beijerinckii

The butyrate producer

Microbe involved in acetate and butyrate production. The short-chain fatty acid (SCFA), butyrate, binds to specific receptors within the gut mucosa and stimulates glucagon-like peptide-1 (GLP-1).

Anaerobutyricum hallii

The other butyrate producer

Microbe involved in acetate and butyrate production.

Clostridium butyricum

The digestive health & immunity booster

Microbe involved in acetate and butyrate production.

Bifidobacterium infantis

The digestive health booster

Microbe involved with improved digestive health by way of acetate production and anti-inflammatory benefits.

Strains Like
No Other

Pendulum Glucose Control is a synbiotic that contains prebiotic inulin as well as 5 anaerobic microbes known to be missing or lacking functionality in individuals with type 2 diabetes.

Pipeline

At Pendulum Therapeutics, we strive to provide therapeutics to people impacted by a variety of conditions by targeting the microbiome. Here's what's in store.

Helpful Resources

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