A breakthrough in microbiome science

The human body is complex. It’s a compilation of cells, systems, and processes, all aided by microorganisms that work together to help keep us healthy. This is the microbiome, and it’s the key to unlocking metabolic health and wellness.

Shop Now

A1C Reduction 1

-0.6%

Post Prandial Glucose spike reduction 2

-32.5%

Our clinical trial.

We conducted a double-blind, placebo-controlled nutrition study that demonstrated:

- Pendulum Glucose Control’s safety

- Pendulum Glucose Control statistically and clinically significant impact on A1C and post-meal blood-glucose spikes

Clinical trial included participants taking metformin, compared to placebo. 1. Regarding the decreased A1C level, there was a reduction in mean A1C compared to placebo. 2. Regarding the Post Prandial Glucose Spike Reduction, the observed reduction in glucose AUC would be expected to increase the time spent within the healthy glucose range (TIR70-180) during continuous glucose monitoring. Increases in TIR70-180 strongly correlate to both reductions in AC1C and reduction in risk for complications in T2D patients (see details here).

Read the Study

The link between metabolism and microbiome.

Research has shown that Type 2 diabetes is linked to an imbalance in the gut microbiome. Specifically, people with diabetes are shown to have low levels of Akkermansia muciniphila and other probiotic strains that help digest dietary fiber to produce butyrate, a crucial short-chain fatty acid needed for balancing glucose and supporting the gut lining.

The science behind Pendulum’s main product, Pendulum Glucose Control, has demonstrated that it helps lower A1C and manage blood sugar spikes in people with Type 2 diabetes taking metformin.

Butyrate: A powerful byproduct in a balanced microbiome.

Butyrate is critically important for digestive and metabolic health. It feeds the cells in our gut and creates a favorable environment for other good bacteria to grow. More than 5,000 research studies have shown that butyrate plays several important roles in the body:

1 Major fuel source for cells lining the large intestine.
2 Helping maintain the gut lining.
3 Helps improve immunity by defending against permeability.
4 Stimulates GLP-1, a hormone produced by the gut, which helps maintain a healthy balance between insulin and glucose levels.
5 Helps manage certain symptoms of Type 2 diabetes.

But, our bodies don’t produce any butyrate on their own.

So Pendulum has compiled a proprietary blend of bacterial strains that can help your body generate butyrate. Pendulum Glucose Control is the only probiotic to contain the combination of Akkermansia muciniphila, Clostridium beijerinckii, Clostridium butyricum, Bifidobacterium infantis, and Anaerobutyricum hallii that helps people maintain their own healthy microbiomes.

Shop Glucose Control

Our strains deserve a spotlight

Introducing the powerful ingredients in our Glucose Control probiotic blend.

Akkermansia muciniphila

The gut-lining builder

A highly targeted strain that can only be found in Pendulum Glucose Control & Akkermansia products. People with Type 2 diabetes are shown to be deficient in Akkermansia, which can be associated with healthy weight management.

Clostridium butyricum

The digestive health & immunity booster

Naturally found in the human GI tract, this strain is named for its ability to produce high amounts of the short-chain fatty acid butyrate. It has been associated with digestion support and immune health.

Clostridium beijerinckii

The butyrate producer

This novel strain produces the short-chain fatty acid butyrate, which helps the body process sugar and nourish the lining of the gut.

Anaerobutyricum hallii

The other butyrate producer

Have we mentioned the importance of butyrate? This is another strain known to produce the short-chain fatty acid butyrate, helping the body process sugar and nourish the lining of the gut.

Bifidobacterium infantis

The digestive health booster

This heavy-hitter breaks down a range of foods and produces the intermediate molecules that are used by the three butyrate-producing strains we have. It also helps maintain a healthy GI tract and alleviates digestive issues.

Chicory inulin

The power source for our strains

A soluble fiber that can travel to the lower gut and feed our strains. We want to enhance our strains' abilities to perform their targeted functions.

No one could manufacture these novel strains—so we built our own facility.

The Pendulum manufacturing facility is as unique as the probiotic strains grown within it. Why? Our strains are the heavy-hitters, the ones that live and thrive where there’s absolutely no oxygen - in your colon - and they can only exist in a comparable environment.

Anaerobic probiotics require a completely oxygen-free environment.

In order to grow Akkermansia and our other strict anaerobes, we had to create our own closed-system facility to ensure the complete absence of oxygen from start to finish.

Fun Facts

How probiotics actually reach the large intestine

To make it through the digestive tract, live cultures need to be a high-quality robust strain, otherwise their journey will be over before it’s begun!

In a high-quality probiotic supplement, the strains will have the following features:
- Survive stomach acidity
- Reach the gut alive
- Inhibit the growth of pathogens (harmful microbes)

Pendulum helps get our powerful strains to your intestine utilizing our enteric coated capsule!

What’s so special about Pendulum’s capsule?

Pendulum's enteric coated capsule is acid-resistant, meaning it is tough enough to get past the very acidic stomach, and only start releasing the formulation in the intestine where our strains can do their jobs.

How rare is Akkermansia muciniphila?

Akkermansia isn’t just a new strain, it’s a rare one. Part of what makes Akkermansia so uncommon - and why you can’t find it in any products other than Pendulum’s - is the fact that it’s a strict anaerobic probiotic strain, meaning it can only exist in completely oxygen-free environments. This makes it tricky to manufacture. Not to mention the technology it takes to identify and grow Akkermansia. This is called high-resolution DNA sequencing, and it allows our scientists to see at the species - or strain - level, which they can then isolate and sequence to grow more.

We’re honored to serve alongside our prestigious board members.

Board of Directors

Adam D’augelli

Partner
True Ventures

Colleen Cutcliffe

CEO
pendulum therapeutics

Craig Sherman, General Partner

Meritech Capital

Heather Mason

Fmr. SVP
Abbott Nutrition

Fmr. SVP
Abbott Diagnostics

Hugh Martin

CEO
Lacuna Technologies
Sensity Biosystems (acq Verizon)
Pacific Biosciences (IPO)
ONI Systems (IPO)

John Eid

CSO
pendulum therapeutics

Peter Barton Hutt, Senior Counsel

Senior Counsel
Covington & Burling

Fmr. General Counsel
FDA

Roelof Botha

Seed & Early, Growth Partner
Sequoia Capital

Medical Advisory Board

Anne Peters, MD

Director, Clinical Diabetes
University of Southern California Private Practice

Carol Wysham, MD

Professor
University of Washington

Practitioner
Rockwood Multicare Center for Diabetes

Davida Krueger, NP

Nurse Practitioner
Henry Ford Health System

Chair
American Diabetes Association (ADA) Research Foundation

Emeran Mayer, MD

Director, Oppenheimer Center For Neurobiology of Stress and Resilience

Professor, Department of Medicine
UCLA

Jay Pasricha, MD

Director, Neurogastroenterology Vice Chair, Medicine Innovation and Commercialization
Johns Hopkins University

John Buse, MD

Chair, Division of Endocrinology
University of North Carolina School of Medicine

Linda Nguyen, MD

Associate Professor, Gastroenterology and Hepatology
Stanford University

Purna Kashyap, MBBS

Associate Professor, Medicine
Mayo Clinic

Robert Ratner, MD

Chief Medical Officer
Virta Health

Fmr Chief Scientific & Medical Officer
American Diabetes Association

Scientific Advisory Board

Alfred Spormann, Ph.D.

PROFESSOR, CIVIL AND ENVIRONMENTAL ENGINEERING
STANFORD UNIVERSITY

Chris Mason, Ph.D.

CEO
SEMA4

DEAN PRECISION MEDICINE
MOUNT SINAI MEDICINE

Dietrich Stephan, Ph.D.

CEO
NEUBASE THERAPEUTICS

CHAIR, DEPARTMENT OF HUMAN GENETICS
UNIVERSITY OF PITTSBURGH

Eric Schadt, Ph.D.

PROFESSOR, CIVIL AND ENVIRONMENTAL ENGINEERING
STANFORD UNIVERSITY

Peter Turnbaugh, Ph.D.

ASSISTANT PROFESSOR, DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY
UCSF