A breakthrough in microbiome science

A breakthrough in microbiome science

The human body is complex. It’s a compilation of cells, systems, and processes, all aided by microorganisms that work together to help keep us healthy. This is the microbiome, and it’s the key to unlocking metabolic health and wellness.

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A1C Reduction 1
-0.6%
Post Prandial Glucose spike reduction 2
-32.5%

Our clinical trial.

We conducted a double-blind, placebo-controlled nutrition study that demonstrated:

- Pendulum Glucose Control’s safety

- Pendulum Glucose Control statistically and clinically significant impact on A1C and post-meal blood-glucose spikes 

Clinical trial included participants taking metformin, compared to placebo. 1. Regarding the decreased A1C level, there was a reduction in mean A1C compared to placebo. 2. Regarding the Post Prandial Glucose Spike Reduction, the observed reduction in glucose AUC would be expected to increase the time spent within the healthy glucose range (TIR70-180) during continuous glucose monitoring.  Increases in TIR70-180 strongly correlate to both reductions in AC1C and reduction in risk for complications in T2D patients (see details here).

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The link between metabolism and microbiome.

Research has shown that Type 2 diabetes is linked to an imbalance in the gut microbiome. Specifically, people with diabetes are shown to have low levels of Akkermansia muciniphila and other probiotic strains that help digest dietary fiber to produce butyrate, a crucial short-chain fatty acid needed for balancing glucose and supporting the gut lining.

The science behind Pendulum’s main product, Pendulum Glucose Control, has demonstrated that it helps lower A1C and manage blood sugar spikes in people with Type 2 diabetes taking metformin. 

Butyrate: A powerful byproduct in a balanced microbiome.

Butyrate is critically important for digestive and metabolic health. It feeds the cells in our gut and creates a favorable environment for other good bacteria to grow. More than 5,000 research studies have shown that butyrate plays several important roles in the body:

  • 1 Major fuel source for cells lining the large intestine.
  • 2 Helping maintain the gut lining.
  • 3 Helps improve immunity by defending against permeability.
  • 4 Stimulates GLP-1, a hormone produced by the gut, which helps maintain a healthy balance between insulin and glucose levels.
  • 5 Helps manage certain symptoms of Type 2 diabetes.

But, our bodies don’t produce any butyrate on their own.

So Pendulum has compiled a proprietary blend of bacterial strains that can help your body generate butyrate. Pendulum Glucose Control is the only probiotic to contain the combination of Akkermansia muciniphila, Clostridium beijerinckii, Clostridium butyricum, Bifidobacterium infantis, and Anaerobutyricum hallii that helps people maintain their own healthy microbiomes.
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So Pendulum has compiled a proprietary blend of bacterial strains that can help your body generate butyrate. Pendulum Glucose Control is the only probiotic to contain the combination of Akkermansia muciniphila, Clostridium beijerinckii, Clostridium butyricum, Bifidobacterium infantis, and Anaerobutyricum hallii that helps people maintain their own healthy microbiomes.
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No one could manufacture these novel strains—so we built our own facility.

The Pendulum manufacturing facility is as unique as the probiotic strains grown within it. Why? Our strains are the heavy-hitters, the ones that live and thrive where there’s absolutely no oxygen - in your colon - and they can only exist in a comparable environment.

Anaerobic probiotics require a completely oxygen-free environment.

In order to grow Akkermansia and our other strict anaerobes, we had to create our own closed-system facility to ensure the complete absence of oxygen from start to finish.

Fun Facts

How probiotics actually reach the large intestine

To make it through the digestive tract, live cultures need to be a high-quality robust strain, otherwise their journey will be over before it’s begun!

In a high-quality probiotic supplement, the strains will have the following features:
- Survive stomach acidity
- Reach the gut alive
- Inhibit the growth of pathogens (harmful microbes)

Pendulum helps get our powerful strains to your intestine utilizing our enteric capsule!

What’s so special about Pendulum’s capsule?

Pendulum's enteric capsule is acid-resistant, meaning it is tough enough to get past the very acidic stomach, and only start releasing the formulation in the intestine where our strains can do their jobs.

How rare is Akkermansia muciniphila?

Akkermansia isn’t just a new strain, it’s a rare one. Part of what makes Akkermansia so uncommon - and why you can’t find it in any products other than Pendulum’s - is the fact that it’s a strict anaerobic probiotic strain, meaning it can only exist in completely oxygen-free environments. This makes it tricky to manufacture. Not to mention the technology it takes to identify and grow Akkermansia. This is called high-resolution DNA sequencing, and it allows our scientists to see at the species - or strain - level, which they can then isolate and sequence to grow more.