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Take Control of Your Gut

A gut microbiome breakthrough for type 2 diabetes

Emerging research shows that type 2 diabetes (T2D) is linked to an imbalance in the gut microbiome. Over time, people with T2D have lost beneficial bacterial strains that help digest dietary fiber and produce butyrate (a key molecule needed for balancing insulin and glucose levels). Research shows there are 3 components to battling diabetes: diet, exercise and the microbiome. This helps explain why diet and exercise are often not enough to keep blood glucose under control. [1-3, 36]

The important connection between the gut microbiome and T2D has been widely recognized by the American Diabetes Association, Mayo Clinic, Johns Hopkins, and others. [13-15] 

The first and only Medical Probiotic for type 2 diabetes

Pendulum Glucose Control (PGC) is a synbiotic that contains targeted strains of probiotics (beneficial bacteria) and a prebiotic (food to fuel bacteria), which helps the body manage healthy A1C and blood glucose levels. As a Medical Probiotic, PGC is:

Clinically tested. PGC has been clinically shown to help people with type 2 diabetes (T2D) manage healthy A1C levels and glucose spikes. These results were presented at the American Diabetes Association's 79th Scientific Sessions.

Targeted. PGC is designed for people with T2D to increase the gut microbiome’s butyrate-producing and mucin-regulating functions.

Novel. Our unique, patented formula includes targeted strains discovered through DNA sequencing. 

Clinically-shown efficacy

In a randomized, double-blinded, placebo controlled, multi-site study, PGC demonstrated statistically significant reductions in A1C and blood sugar spikes in people with T2D.* PGC also showed incremental improvement in A1C levels in people already taking metformin.

“We found Pendulum Glucose Control to be safe, well-tolerated, and an effective way to help those living with type 2 diabetes manage their disease,” says Dr. Damaris Vega, endocrinologist, Juno Research LLC. 

To review the full study, click here.

*A nutrition study demonstrated significant reduction in A1C and blood sugar spikes in people with type 2 diabetes.  It was randomized, double-blinded, placebo controlled, and across multiple sites in the U.S. 

The first probiotic registry with the Mayo Clinic

We've partnered with leading researchers at the Mayo Clinic to create the first Mayo Registry for a medical probiotic.  The Mayo Clinic has been a leader in advancing microbiome science through the Mayo Microbiome Program. The Mayo Clinic is compiling and reporting results from PGC customers who voluntarily and anonymously share their data. All PGC customers are eligible to participate in this important scientific endeavor. 

Butyrate: essential for glucose balance

PGC delivers targeted beneficial bacterial strains to the gut microbiome for people with T2D to help restore lost functionality of metabolizing fiber into butyrate.

Butyrate is a short chain fatty acid critical to digestive health, a healthy metabolism and healthy blood glucose levels. Over 5,000 research studies have shown that butyrate plays several important roles in the gut. It’s a major fuel source for cells lining the large intestine and is involved in improving immunity and reducing inflammation. Butyrate also plays a role in stimulating GLP-1 (a hormone produced by the gut) secretion, which helps maintain a healthy balance between insulin and glucose levels. [5, 6,8, 9, 24-30]

*Figure adapted from "Alterations in Gut Microbiota and Immunity by Dietary Fat", Yonsei Medical Journal 58(6):1083, November 2017.  https://www.researchgate.net/publication/320492093_Alterations_in_Gut_Microbiota_and_Immunity_by_Dietary_Fat

Butyrate and mucin: key to immune health

PGC helps your body produce more butyrate and mucin to maintain a healthy gut microbiome and strengthen the immune system.

Butyrate signals to the immune system when immune defenses need to ramp up. When there is not enough butyrate production in the microbiome, the immune system is compromised. 

Mucin protects your gut lining (and ultimately the immune system). PGC contains novel strain Akkermansia muciniphila, which helps modulate the gut lining. People with diabetes are shown to have lower levels of Akkermansia and gut lining modulation. A strong gut lining is vital to ensure that small molecules in the gut don't “leak” across the gut lining into the bloodstream, which can cause heightened inflammation and compromise the immune system. [33-34] 

Akkermansia muciniphila WB-STR-0001 (gut lining probiotic)

A unique and novel bacterial strain that can only be found in PGC. This strain was first identified by Dr. Lee Kaplan, Associate Professor of Medicine at Harvard School of Medicine and Director of the Obesity, Metabolism and Nutrition Institute. Over 800 studies have been published on Akkermansia muciniphila and have shown that many people with diabetes and heightened inflammation have lower amounts than healthy people. Akkermansia muciniphila is naturally found in your gastrointestinal (GI) tract, where it directly interacts with the gut lining and helps regulate the mucus lining of the gut. This strain also helps maintain a healthy ecosystem of beneficial bacteria in the GI. [11, 12, 16, 31]

Eubacterium hallii WB-STR-0008 (butyrate-producing probiotic)

A unique and novel bacterial strain that can only be found in PGC. Many studies have shown that people with diabetes and prediabetes are low in or entirely missing this strain, whereas healthy people have it in vast abundance in their guts. This strain is an important microbe for intestinal metabolic balance due to its ability to utilize glucose to form butyrate. [32] 

Clostridium butyricum WB-STR-0006 (digestive and immune health probiotic) 

Naturally found in the human gut microbiome, this strain is named for its ability to produce high amounts of butyrate. It's been clinically shown to support healthy gut microflora, digestion and immune health. It's also been shown to help relieve irritable bowel syndrome (IBS) symptoms including reducing abdominal pain, gas and bloating. [17-19]

Clostridium beijerinckii WB-STR-0005 (butyrate-producing probiotic) 

Naturally found in the human GI tract, this strain produces butyrate. [33]

Bifidobacterium infantis 100 (digestive health probiotic) 

A common bacterial strain naturally found in the human oral cavity and GI tract. This strain helps maintain a healthy digestive tract and has been shown to help relieve IBS symptoms including reducing abdominal pain, gas and bloating. [20, 21] 

Inulin (healthy blood sugar prebiotic)

A soluble fiber sourced from chicory root. Inulin is classified as a prebiotic because of its ability to travel to the lower gut and stimulate the growth of beneficial bacteria, including the bacterial strains in our product. Studies have shown supplementation with inulin helps lower fasting blood sugar, reduce fasting insulin, and improve "good" (HDL) cholesterol in people with T2D. [22, 23]

Our Chief Medical Officer is a diabetes pioneer

Our medical research team is led by Chief Medical Officer, Orville Kolterman, M.D., a well-respected diabetes expert based on his contributions to diabetes drug development and the diabetes community. Dr. Kolterman was previously the Chief Medical Officer at Amylin Pharmaceuticals, where he successfully brought four diabetes drugs from early-stage development through trials and to market.  

Together with Dr. Kolterman, we work with leading diabetes professionals to ensure that our products deliver exceptional results and meet the highest standards of efficacy and safety. 

Dr. Kolterman received his MD from Stanford University School of Medicine, performed his residency in Internal Medicine at the University of Chicago and Endocrinology training at Stanford University.

Eric Schadt, PhD 
Scientific Advisory Board Member:

Dean for Precision Medicine, Icahn School of Medicine at Mount Sinai. 

Christopher E. Mason, PhD
Scientific Advisory Board Member:

Associate Professor of Integrative Functional Genomics, Clinical Genetics and Synthetic Biology at Weill Cornell Medical College. 

Alfred Spormann, PhD
Scientific Advisory Board Member:

Professor in Civil and Environmental Engineering at Stanford University. 

Marion Leclerc, PhD
Scientific Advisory Board Member:

Team Leader at the French National Institute for Agricultural Research. 

Dietrich Stephan, PhD
Scientific Advisory Board Member:

Professor and Chair of the Department of Human Genetics at the University of Pittsburgh Graduate School of Public Health. 

Peter Turnbaugh, PhD
Scientific Advisory Board Member:

Assistant Professor of Department of Microbiology and Immunology for G.W. Hooper Research Foundation at University of California, San Francisco. 

John Buse, MD, PhD
Medical Advisory Board Member:

Verne S. Caviness Distinguished Professor, Chief of the Division of Endocrinology, Director of the Diabetes Center, Director of the NC Translational and Clinical Sciences Institute and Executive Associate Dean for Clinical Research at the University of North Carolina (UNC) School of Medicine in Chapel Hill. 

Carol Wysham, MD
Medical Advisory Board Member:

Clinical Professor of Medicine at the University of Washington School of Medicine and is Clinical Endocrinologist at Rockwood Multicare Center for Diabetes and Endocrinology in Spokane, Washington. 

Emeran Mayer, MD
Medical Advisory Board Member:

Gastroenterologist, Neuroscientist and Professor in the Departments of Medicine, Physiology and Psychiatry at the David Geffen School of Medicine at UCLA. 

Jay Pasricha, MD
Medical Advisory Board Member:

Director of the Johns Hopkins Center for Neurogastroenterology, Professor of Medicine and Vice Chair of Medicine Innovation and Commercialization. 

Anne L. Peters, MD
Medical Advisory Board Member:

Professor of Clinical Medicine at the Keck School of Medicine of the University of Southern California and Director of the USC Clinical Diabetes Programs. 

Robert Ratner, MD
Medical Advisory Board Member:

Former Chief Scientific & Medical Officer for the American Diabetes Association. 

Davida F. Kruger, MSN, APN-BC, BC-ADM
Medical Advisory Board Member:

Certified Nurse Practitioner in diabetes at Henry Ford Health System. 

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