Take Control of Your Gut

Your gut microbiome is an ecosystem that contains trillions of bacterial organisms. These live microorganisms, also known as beneficial bacteria, can play key roles in gut function and overall health.

Diabetes and the Microbiome

Diet and exercise are important to keep blood glucose under control, but often they’re not enough. Why? As we age, we get exposed to different environments and different stresses, our bodies lose specific beneficial bacteria that allow it to process carbohydrates, sugars and fibers effectively. These beneficial bacteria live along the length of your digestive tract and metabolize the food you eat, extracting beneficial nutrients from your diet. Without these microbes, your body cannot capture these nutrients and enzymes. Over time, your body loses its ability to keep your blood glucose under control.

Pendulum Glucose Control: The First Medical Probiotic for Diabetes

Pendulum Glucose Control capsules are specifically designed for people with type 2 diabetes. They contain targeted strains of probiotics and a prebiotic that help restore the body’s natural ability to metabolize fiber in order to maintain healthy A1C and blood glucose levels.

How it Works

Pendulum Glucose Control is a medical probiotic that contains targeted strains of probiotics (beneficial bacteria) and a prebiotic (food to fuel bacteria). This combination nourishes your ecosystem, enabling your body to increase butyrate production which assists in maintaining glucose control.

Good Gut Bacteria: Contains a blend of probiotics and a prebiotic that helps produce a beneficial short-chain fatty acid called butyrate. Butyrate is a key molecule needed to maintain insulin and glucose balance.

Blood Sugar: Shown in a clinical trial to reduce post-meal glucose spikes and A1C levels.*

Fiber Metabolism: Helps break down fiber to aid the body’s production of the metabolite butyrate, shown to be deficient in type 2 diabetes patients.

Gut Lining: Helps protect the gut lining in the intestines by helping prevent harmful bacteria from causing inflammation in the gut.

Butyrate Microbes - The Super Hero

People with type 2 diabetes have been shown to be deficient in the specific gut microbes that metabolize fibers into short-chain fatty acids, like butyrate. Butyrate is a key molecule needed to maintain insulin and glucose balance.

Doctor Recommended

Our medical research team is led by Chief Medical Officer, Orville Kolterman, M.D., a well-respected diabetes expert in the field based on his contributions in drug development and to the Diabetes community. Dr. Kolterman was previously the Chief Medical Officer at Amylin Pharmaceuticals, where he brought four diabetes drugs from early stage development through trials and to market.

Dr. Kolterman served as the President of the California Affiliate of the American Diabetes Association and is an Adjunct Professor of Medicine at the University of California, San Diego. Dr. Kolterman received his MD from Stanford University School of Medicine, performed his residency in Internal Medicine at the University of Chicago and returned to Stanford for his Endocrinology training.

Together with Orville, we work with leading diabetes professionals to ensure that our products deliver exceptional results and meet the highest standards of efficacy and safety.

“Pendulum Glucose Control has shown to deliver significant results and meets our highest standards of safety and efficacy.” Dr. Orville Kolterman, M.D.

Backed By Clinical Research

In a clinical trial, Pendulum Glucose Control was shown to lower A1C levels and reduce post-meal blood sugar spikes in people with type 2 diabetes.*

*A nutrition study demonstrated statistically and clinically significant reduction in A1C and blood sugar spikes in people with type 2 diabetes. It was randomized, double-blinded, placebo controlled, and across multiple sites in the U.S. https://clinicaltrials.gov/ct2/show/NCT03893422?term=Whole+Biome&cond=Type+2+diabetes&cntry=US&state=US%3ACA&age=12&rank=1

Novel and Patented Formula

Pendulum Glucose Control contains a proprietary probiotic blend: Clostridium beijerinckii WB-STR-0005, Clostridium butyricum WB-STR-0006, Akkermansia muciniphila WB-STR-0001, Eubacterium hallii WB-STR-0008, Bifidobacterium infantis 100. This page is intended to serve as notice under 35 U.S.C. § 287(a). [Pendulum Glucose Control] is covered by U.S. Pat. Nos. 9,173,910; 9,486,487; 10,149,867; 10,149,870. Other patents are pending.

Have a Question? We Have Answers

The human microbiome is an ecosystem of trillions of bacteria, viruses and fungi that live on or in our bodies. The microbiome works symbiotically with the body to perform essential tasks from helping digestion, to supporting the development of the immune system and preventing infections. These living microorganisms, also known as beneficial bacteria, can offer diverse health benefits. Read more about the microbiome on our blog: https://pendulumlife.com/blogs/news/the-gut-microbiome-what-you-should-know
Over time, through genetic predispositions, changes to diet and exercise, stress, aging and other factors, our microbiome can lose the strains that help us metabolize food correctly. Specifically, people with type 2 diabetes have been shown to be deficient in certain beneficial bacteria that metabolize fiber (a carb) into useful nutrients and short-chain fatty acids like butyrate. One of the key features of butyrate is that it is responsible for initiating metabolic pathways, specifically GLP-1 and insulin secretion. In people with T2D, who are missing these key strains, the fiber they eat is literally going right through them instead of being metabolized into metabolites such as butyrate, stimulating GLP-1 release, and contributing to insulin and glucose regulation.
As our behaviors and environments evolve and our microbiomes change, many people start to lose diversity of their microbiome. Those changes can result in a reduction or loss of specific functions such as healthy metabolism or appropriate immune responses. In turn, the reduction or losses of functionality can lead to the inability to produce essential vitamins, to fend off bad bacteria, and to metabolize foods. Ultimately, if a microbiome is altered in these ways, it can cause or make a person more susceptible to illness and disease.
Yes, it is possible to make improvements to the microbiome. Changing the diet can help diversify the microbiome (especially diets high in fiber), but is insufficient to obtain specific microbes or replace lost microbiome-driven functions. People with type 2 diabetes have lost part of all of the ability to metabolize fiber and produce butyrate, which helps to manage blood sugar and regulate insulin. Simply replacing butyrate as a supplement isn’t enough as it matters where the butyrate is produced in the gut. In a clinical trial, we were able to demonstrate that one may be able to improve the microbiome of people with type 2 diabetes by adding precise prebiotics and probiotics that provide distinct nutritional requirements specific to the disease.
We conducted a nutrition study that demonstrated safety and tolerability, as well as statistically and clinically significant reductions in A1C and blood sugar spikes in people with type 2 diabetes. It was randomized, double-blinded, placebo controlled, and across multiple sites in the U.S. Read more about the study here: https://diabetes.diabetesjournals.org/content/68/Supplement_1/758-P
We have several preclinical and clinical assessments of safety using the Pendulum Glucose Control product. We have shown safety with healthy individuals taking up to 10x the recommended dose. The product was also well-tolerated and did not result in increased adverse event rates compared to placebo in a 12-week, randomized, double-blind, placebo controlled food trial. We have also performed and passed DNA sequencing analysis, virulence factor analysis, antibiotic resistance testing, pathogen testing, and toxicity studies. This and other available data on each individual strain was used to obtain GRAS designation.
Pendulum Glucose Control is a Medical Probiotic that was specifically designed for people with type 2 diabetes. It contains targeted strains of probiotics and a prebiotic that help restore the body’s natural ability to metabolize fiber (a carb) in order to help manage blood sugar. Our combination of targeted probiotic strains cannot be found in any other probiotic on the market and is patented. Patent information: www.pendulumlife.com/science
Our medical research team is led by Chief Medical Officer, Orville Kolterman, M.D., a well-respected diabetes expert in the field based on his contributions in drug development and to the Diabetes community. Dr. Kolterman was previously the Chief Medical Officer at Amylin Pharmaceuticals, where he brought four diabetes drugs from early stage development through trials and to market. Dr. Kolterman served as the President of the California Affiliate of the American Diabetes Association and is an Adjunct Professor of Medicine at the University of California, San Diego. Dr. Kolterman received his MD from Stanford University School of Medicine, performed his residency in Internal Medicine at the University of Chicago and returned to Stanford for his Endocrinology training. Together with Dr. Orville, we work with leading diabetes professionals to ensure that our products deliver exceptional results and meet the highest standards of efficacy and safety. “Pendulum Glucose Control has shown to deliver significant results and meets our highest standards of safety and efficacy.” Dr. Orville Kolterman, M.D.

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Take Control of Your Gut