AUC Relevance: Demonstrate that a 32.5% decrease in incremental glucose AUC (iAUC) during a standardized meal tolerance test is both clinically meaningful and clinically relevant. Response: Recent continuous glucose monitoring (CGM) publications provide the necessary support. Figure 1A displays daily CGM in the format recommended by the International Consensus Conference convened to standardize the approach to CGM data.¹ Inspection of the plot reveals 3 clear peaks in glucose values corresponding...