What is Clostridium Butyricum?

Written by Harcharan Kaur — April 22, 2021

What is Clostridium Butyricum?

What is clostridium butyricum (and how does it affect your health)?

Clostridium butyricum is a type of beneficial bacteria that can naturally be found in the gut microbiome.

An increasing amount of evidence suggests that species of beneficial gut bacteria have the potential to help us manage a wide range of health conditions.

  • Clostridium butyricum is a common type of bacteria found in soil and in the human gut
  • Clostridium butyricum is best known for its ability to produce butyratea postbiotic that helps people regulate their blood-sugar levels, prompt serotonin release, and strengthen the gut barrier
  • When added to probiotics, Clostridium butyricum can help people manage Type 2 diabetes
  • Pendulum Glucose Control is a medical probiotic that contains Clostridium butyricum, and has been shown in a clinical trial to be both safe and effective at managing blood-sugar levels in people with Type 2 diabetes who were also taking metformin

     

    What are the benefits of Clostridium butyricum?

      In the next few sections, we’ll highlight some of the studies that demonstrate the many potential benefits of Clostridium butyricum.

      Clostridium butyricum and Type 2 diabetes

      Though research is ongoing, several studies show that Clostridium butyricum helps with the management of Type 2 diabetes  4,5,10-13

      One group of researchers set out to explore this question by studying the gut microbiome 291 people with and without Type 2 diabetes. They found that the 98 individuals with Type 2 diabetes had—on average— almost half the amount of Clostridium butyricum compared to what was found in participants without Type 2 diabetes. 

      Another recent clinical trial sought to evaluate what benefits could come from restoring multiple bacteria species—including Clostridium butyricum—in the gut microbiome of people with Type 2 diabetes. 

      Pendulum Glucose Control—a medical probiotic that contains Clostridium butyricum—was given to 23 adults with Type 2 diabetes taking metformin for 12 weeks. Researchers discovered that Clostridium butyricum—in combination with the 4 other bacterial species in Pendulum Glucose Control—reduced A1C by as much as 0.6% and reduced after-meal blood \-sugar spikes by 33%.

      Diabetes

      Clostridium butyricum for Irritable Bowel Syndrome

      Clostridium butyricum may also help with the management of Irritable Bowel Syndrome (IBS).

      IBS is a condition where a person feels severe discomfort or pain in their gut and it often comes with constipation, diarrhea, or both. 

      The potential beneficial impact of Clostridium butyricum on IBS was spotlighted in a 2018 clinical trial in which 200 patients with IBS were given either Clostridium butyricum or placebo for four weeks. 

      The severity of their symptoms were tallied up at the beginning of the study and after 4 weeks of treatment.

      Clostridium butyricum treatment led to 50% more improvement in overall symptoms compared to placebo, showing an even stronger effect in those experiencing moderate to severe symptoms. 

      The specific effect of Clostridium butyricum on various symptoms has varied from study to study, but an overall trend has shown that Clostridium butyricum is likely to improve patients’ quality of life.

      Depression

      What does Clostridium butyricum do?

      Clostridium butyricum’s wide ranging effects on the body come from its ability to convert dietary fiber into butyrate.

      Butyrate is a short-chain fatty acid that is known to:

      Because our body isn’t able to produce any butyrate on its own, it depends on microbes like Clostridium butyricum to produce butyrate for us. 

      How do you increase Clostridium butyricum in the gut?

      Research has shown that taking probiotics containing Clostridium butyricum is the most effective way to increase its levels in your gut. 

      And while there are natural sources of Clostridium butyricum—such as soil, certain vegetables, and spoiled dairy products—there’s no evidence suggesting that a certain food or diet would help increase Clostridium butyricum levels.

      Clostridium butyricum probiotics

      For people looking to supplement their diet with a Clostridium butyricum probiotic, there are several options. 

      One of them is Pendulum Glucose Control.

      Pendulum Glucose Control was recently tested in a clinical trial involving patients with Type 2 diabetes taking metformin4

      The results showed that treatment with Pendulum Glucose Control resulted in improved measures of A1C and after-meal blood-sugar levels. 

      PGC

      How many colony forming units (CFUs) of Clostridium butyricum should you take?

      There is no set number for the amount of Clostridium butyricum that should be taken. 

      If you are looking for guidance, consider talking with your healthcare provider and not exceeding the amount suggested by the probiotic manufacturer. 

      Final thoughts

      Over the past decade, scientists have come to see Clostridium butyricum as an important part of the gut microbiome with significant potential as a probiotic. 

      Research is ongoing, but the evidence so far suggests that Clostridium butyricum may be able to help people manage a wide range of conditions.

      For those looking to boost their Clostridium butyricum levels, probiotics are currently the only demonstrated method for increasing Clostridium butyricum in the human gut microbiome.

      References
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      2. Cassir, N., et al. “Clostridium Butyricum : from Beneficial to a New Emerging Pathogen.” Clinical Microbiology and Infection, vol. 22, no. 1, 2016, pp. 37–45., doi:10.1016/j.cmi.2015.10.014. https://pubmed.ncbi.nlm.nih.gov/26493849/ 
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        Before you consider any of these gut-microbiome dietary solutions, talk to your healthcare provider. 
        The FDA has not approved or evaluated these statements. Pendulum products are not intended to diagnose, treat, cure, or prevent any diseases. Results may vary.