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What's inside Pendulum Glucose Control?

Gut microbiome health, Pendulum products

What's inside Pendulum Glucose Control?

Powerful, proven strains to help you manage your blood glucose.

 

Pendulum Glucose Control's patented formula contains 5 targeted probiotic strains (beneficial bacteria) and a prebiotic (food to fuel bacteria). Learn more about each of the strains and the prebiotic below:

 

Akkermansia muciniphila WB-STR-0001 (gut lining probiotic)

A unique and novel bacterial strain that can only be found in PGC. This strain was first identified by Dr. Lee Kaplan, Associate Professor of Medicine at Harvard School of Medicine and Director of the Obesity, Metabolism and Nutrition Institute. Over 800 studies have been published on Akkermansia muciniphila and have shown that many people with diabetes and heightened inflammation have lower amounts than healthy people. Akkermansia muciniphila is naturally found in your gastrointestinal (GI) tract, where it directly interacts with the gut lining and helps regulate the mucus lining of the gut. This strain also helps maintain a healthy ecosystem of beneficial bacteria in the GI.1,2,3,9

Eubacterium hallii WB-STR-0008 (butyrate-producing probiotic)
A unique and novel bacterial strain that can only be found in PGC. Many studies have shown that people with diabetes and prediabetes are low in or entirely missing this strain, whereas healthy people have it in vast abundance in their guts. This strain is an important microbe for intestinal metabolic balance due to its ability to utilize glucose to form butyrate.4

 

Clostridium butyricum WB-STR-0006 (digestive and immune health probiotic) 

Naturally found in the human gut microbiome, this strain is named for its ability to produce high amounts of butyrate. It's been clinically shown to support healthy gut microflora, digestion and immune health. It's also been shown to help relieve irritable bowel syndrome (IBS) symptoms including reducing abdominal pain, gas and bloating.5,6,7,13,14,15

 

Clostridium beijerinckii WB-STR-0005 (butyrate-producing probiotic) 

Naturally found in the human GI tract, this strain produces butyrate.8

 

Bifidobacterium infantis 100 (digestive health probiotic)

A common bacterial strain naturally found in the human oral cavity and GI tract. This strain helps maintain a healthy digestive tract and has been shown to help relieve IBS symptoms including reducing abdominal pain, gas and bloating.10

 

Inulin (healthy blood sugar prebiotic)
A soluble fiber sourced from chicory root. Inulin is classified as a prebiotic because of its ability to travel to the lower gut and stimulate the growth of beneficial bacteria, including the bacterial strains in our product. Studies have shown supplementation with inulin helps lower fasting blood sugar, reduce fasting insulin, and improve "good" (HDL) cholesterol in people with T2D.11,12



References:
  1. A Special Shout Out to Akkermansia Muciniphila.
Diabetes Education Services, November 21, 2019.

  1. A Next-Generation Beneficial Microbe: Akkermansia Muciniphila.
Naito, Y., Uchiyama, K., & Takagi, T. J Clin Biochem Nutr. 2018;63(1):33–35. doi:10.3164/jcbn.18-57

  1. Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies.
Zhou K. Journal of functional foods. 2017.

  1. Mucin Cross-Feeding of Infant Bifidobacteria and Eubacterium hallii.
Bunesova V, Lacroix C, Schwab C. Microb Ecol. 2018 Jan;75(1):228-238.

  1. Anti-diabetic Effects of Clostridium butyricum CGMCC0313.1 through Promoting the Growth of Gut Butyrate-producing Bacteria in Type 2 Diabetic Mice

Jia, L. et al. Sci. Rep. 7, 7046 (2017).

  1. Prevention of antibiotic‐associated diarrhea in children by Clostridium butyricum MIYAIRI

Seki, H. et al. Pediatr. Int. 45, 86–90 (2003).

  1. Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells.

Jia, L. et al. Front. Immunol. 8, 1345 (2017).


  1. How to Use the Probiotic Bifidobacterium Infantis
Healthline.com. 2020.

  1. Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis
Ansaldo E, Slayden LC, Ching KL, et al. Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis. Science. 2019. Vol. 364, Issue 6446, pp. 1179-1184

  1. A gastroenterologist's guide to probiotics.
Ciorba MA. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association. 2012. 

  1. What to know about inulin 101, a powerful prebiotic
Spritzler, F. Medical News Today. 2017.

  1. The Health Benefits of Inulin

Cervoni B. Verywell Health. 2020.

 

  1. The effect of Clostridium butyricum on symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial.

Sun, Y.-Y. et al. Sci. Rep. 8, 2964 (2018).

 

  1. Clostridium butyricum Modulates the Microbiome to Protect Intestinal Barrier Function in Mice with Antibiotic-Induced Dysbiosis.

Hagihara, M. et al. iScience 23, 100772 (2020).

 

  1. A breakthrough in probiotics: Clostridium butyricum regulates gut homeostasis and anti-inflammatory response in inflammatory bowel disease.

Kanai, T., Mikami, Y. & Hayashi, A. J. Gastroenterol. 50, 928–939 (2015).

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